It is also appropriate use on regular basis in Tibb-e-Nabwi (Prophetic Medicine)[3].
The fruit can be a large and inflated capsule consists of 3-7 united follicles, each containing numerous seeds[9],[11].
sativa is of immense therapeutic benefit in diabetic individuals and people with glucose intolerance the way it accentuates glucose-induced secretion of insulin besides developing a negative affect on glucose absorption in the intestinal mucosa[52]. The effects on the TQ in STZ-induced diabetes in rats were investigated. The Effect of N. sativa seeds within the glycemic control over patients with diabetes mellitus was investigated this year. N. It seemed to be demonstrate that in vivo treatment with NSE exerts an insulin-sensitizing action by enhancing ACC phosphorylation, a major aspect of the insulin-independent AMPK signaling pathway, through enhancing muscle Glut4 content
sativa in mammary carcinoma[65]. TQ suppressed the migration and invasion of Panc-1 cells inside a dose-dependent manner. It was also found out that TQ significantly down-regulates NF-kappa B and MMP-9 in Panc-1 cells. In addition, metastatic model simulating human pancreatic cancer was established by orthotropic implantation of histologically intact pancreatic tumor tissue to the pancreatic wall of nude mice. And administration of TQ significantly reduced tumor metastasis in comparison with untreated control. Furthermore, the expression of NF-kappa B and MMP-9 in tumor tissues has also been suppressed after treatment with TQ. TQ exerts anti-metastatic activity on pancreatic cancer in both vitro plus vivo, which could be in connection with down-damaging NF-kappa B as well as its regulated molecules for example MMP-9 protein. Consequently, these results provide important insights into TQ as a possible anti-metastatic agent for the therapy for human pancreatic cancer[66]. The chemo-sensitizing effect of TQ and 5-fluorouracil (5-FU) on gastric cancer cells at vitro plus in vivo is reported by Lei et al. Pre-treatment with TQ significantly increased the apoptotic effects induced by 5-FU in gastric cancer cell lines in vitro. TQ also enhanced the 5-FU-induced killing of gastric cancer cells by mediating the down-regulation with the anti-apoptotic protein bcl-2, the up-regulation from the pro-apoptotic protein bax, plus the activation of both caspase-3 and caspase-9. And further, the combined therapy for TQ with 5-FU represents a significantly far better antitumor agent than either agent alone within a xeno-graft tumor mouse model. This study suggested which the TQ/5-FU combined treatment induces apoptosis by enhancing the activation of both caspase-3 and caspase-9 in gastric cancer cells[67].
The aqueous extract of N. sativa was discovered to possess anti-inflammatory and analgesic yet not antipyretic activities in animal models while anti-inflammatory effect with the alcoholic extracts of N. sativa seeds as well as callus on mix glial cells of rat with regard to their TQ content was investigated. The mix glial cells, inflamed by lipopolysaccharide, were afflicted by anti-inflammatory studies inside presence of assorted amounts of TQ and also the alcoholic extracts. Results confirmed that TQ content with the callus of leaf was 12 times more than that measured within the seeds extract.
The fruit can be a large and inflated capsule consists of 3-7 united follicles, each containing numerous seeds[9],[11].
sativa is of immense therapeutic benefit in diabetic individuals and people with glucose intolerance the way it accentuates glucose-induced secretion of insulin besides developing a negative affect on glucose absorption in the intestinal mucosa[52]. The effects on the TQ in STZ-induced diabetes in rats were investigated. The Effect of N. sativa seeds within the glycemic control over patients with diabetes mellitus was investigated this year. N. It seemed to be demonstrate that in vivo treatment with NSE exerts an insulin-sensitizing action by enhancing ACC phosphorylation, a major aspect of the insulin-independent AMPK signaling pathway, through enhancing muscle Glut4 content
sativa in mammary carcinoma[65]. TQ suppressed the migration and invasion of Panc-1 cells inside a dose-dependent manner. It was also found out that TQ significantly down-regulates NF-kappa B and MMP-9 in Panc-1 cells. In addition, metastatic model simulating human pancreatic cancer was established by orthotropic implantation of histologically intact pancreatic tumor tissue to the pancreatic wall of nude mice. And administration of TQ significantly reduced tumor metastasis in comparison with untreated control. Furthermore, the expression of NF-kappa B and MMP-9 in tumor tissues has also been suppressed after treatment with TQ. TQ exerts anti-metastatic activity on pancreatic cancer in both vitro plus vivo, which could be in connection with down-damaging NF-kappa B as well as its regulated molecules for example MMP-9 protein. Consequently, these results provide important insights into TQ as a possible anti-metastatic agent for the therapy for human pancreatic cancer[66]. The chemo-sensitizing effect of TQ and 5-fluorouracil (5-FU) on gastric cancer cells at vitro plus in vivo is reported by Lei et al. Pre-treatment with TQ significantly increased the apoptotic effects induced by 5-FU in gastric cancer cell lines in vitro. TQ also enhanced the 5-FU-induced killing of gastric cancer cells by mediating the down-regulation with the anti-apoptotic protein bcl-2, the up-regulation from the pro-apoptotic protein bax, plus the activation of both caspase-3 and caspase-9. And further, the combined therapy for TQ with 5-FU represents a significantly far better antitumor agent than either agent alone within a xeno-graft tumor mouse model. This study suggested which the TQ/5-FU combined treatment induces apoptosis by enhancing the activation of both caspase-3 and caspase-9 in gastric cancer cells[67].
The aqueous extract of N. sativa was discovered to possess anti-inflammatory and analgesic yet not antipyretic activities in animal models while anti-inflammatory effect with the alcoholic extracts of N. sativa seeds as well as callus on mix glial cells of rat with regard to their TQ content was investigated. The mix glial cells, inflamed by lipopolysaccharide, were afflicted by anti-inflammatory studies inside presence of assorted amounts of TQ and also the alcoholic extracts. Results confirmed that TQ content with the callus of leaf was 12 times more than that measured within the seeds extract.