It is also appropriate for use on regular basis in Tibb-e-Nabwi (Prophetic Medicine)[3].
The fruit is usually a large and inflated capsule made up of 3-7 united follicles, each containing numerous seeds[9],[11].
Oral administration of TQ at 20, 40, 80 mg/kg weight for 45 d, dose dependently improved the glycemic status in STZ-NA induced diabetic rats. The levels of insulin, Hb increased with significant reduction in glucose and HbA (1C) levels. The altered activities of carbohydrate metabolic enzymes were restored to near normal. These results proved that TQ at 80 mg/kg body mass is regarding beneficial modifications to hepatic enzyme activities and thereby exerts potential anti-hyperglycemic effects[49]. The N. sativa showed the synergistic effect with human parathyroid hormone in improving bone mass, connectivity, biomechanical behavior and strength in insulin-dependent diabetic rats and discovered to be more effective when compared with the treatment with N. sativa or human parathyroid hormone alone[50]. In a clinical study, the adjuvant effect of N. sativa oil on various clinical and biochemical parameters from the insulin resistance syndrome were investigated. N. sativa oil is discovered to be effective being an add-on therapy in patients of insulin resistance syndrome. N. sativa oil has a substantial activity in diabetic and dyslipidemic patients[51]. N. sativa is of immense therapeutic benefit in diabetic individuals and the ones with glucose intolerance mainly because it accentuates glucose-induced secretion of insulin besides using a negative influence on glucose absorption in the intestinal mucosa[52]. The effects on the TQ in STZ-induced diabetes in rats were investigated. The Effect of N. sativa seeds about the glycemic management of patients with type two diabetes mellitus was investigated this season. N. sativa seeds were used for an adjuvant therapy in patients with diabetes mellitus type 2 included with their anti-diabetic medications. N. sativa in a dose of 2 gm/day caused significant reductions in fasting ... sugar, 2 h postprandially (2 hPG), and glycosylated hemoglobin (HbA1c) without significant change in body mass. The results indicate that the dose of 2 gm/day of black seed generally is a beneficial adjuvant to oral hypoglycemic agents in type 2 diabetic patients[53]. The in vivo antidiabetic activity of N. sativa seed ethanol extract (NSE) was evaluated in diabetic Meriones shawi. Plasma lipid profile, insulin, leptin, and adiponectin levels were assessed. ACC phosphorylation and Glut4 protein content were determined in liver and skeletal muscle. NSE animals showed a progressive normalization of glycaemia. It seemed to be demonstrate that in vivo treatment with NSE exerts an insulin-sensitizing action by enhancing ACC phosphorylation, a major portion of the insulin-independent AMPK signaling pathway, and also by enhancing muscle Glut4 content
In vitro study of TQ to view whether or not TQ can increase survival and sustain the expression with the homing receptor CD62L in antigen-specific T cells. The results revealed that stimulation of OT-1 (transgenic CD+) T cells with OVA antigen ended in activation, as shown by the decrease from the surface expression of CD62L which coincided with significant apoptosis measured three and five days after antigen stimulation. Addition of low concentrations of TQ during CD85+ T-cell activation led to enhanced survival with the activated T cells and sustained expression of CD62L.
The fruit is usually a large and inflated capsule made up of 3-7 united follicles, each containing numerous seeds[9],[11].
Oral administration of TQ at 20, 40, 80 mg/kg weight for 45 d, dose dependently improved the glycemic status in STZ-NA induced diabetic rats. The levels of insulin, Hb increased with significant reduction in glucose and HbA (1C) levels. The altered activities of carbohydrate metabolic enzymes were restored to near normal. These results proved that TQ at 80 mg/kg body mass is regarding beneficial modifications to hepatic enzyme activities and thereby exerts potential anti-hyperglycemic effects[49]. The N. sativa showed the synergistic effect with human parathyroid hormone in improving bone mass, connectivity, biomechanical behavior and strength in insulin-dependent diabetic rats and discovered to be more effective when compared with the treatment with N. sativa or human parathyroid hormone alone[50]. In a clinical study, the adjuvant effect of N. sativa oil on various clinical and biochemical parameters from the insulin resistance syndrome were investigated. N. sativa oil is discovered to be effective being an add-on therapy in patients of insulin resistance syndrome. N. sativa oil has a substantial activity in diabetic and dyslipidemic patients[51]. N. sativa is of immense therapeutic benefit in diabetic individuals and the ones with glucose intolerance mainly because it accentuates glucose-induced secretion of insulin besides using a negative influence on glucose absorption in the intestinal mucosa[52]. The effects on the TQ in STZ-induced diabetes in rats were investigated. The Effect of N. sativa seeds about the glycemic management of patients with type two diabetes mellitus was investigated this season. N. sativa seeds were used for an adjuvant therapy in patients with diabetes mellitus type 2 included with their anti-diabetic medications. N. sativa in a dose of 2 gm/day caused significant reductions in fasting ... sugar, 2 h postprandially (2 hPG), and glycosylated hemoglobin (HbA1c) without significant change in body mass. The results indicate that the dose of 2 gm/day of black seed generally is a beneficial adjuvant to oral hypoglycemic agents in type 2 diabetic patients[53]. The in vivo antidiabetic activity of N. sativa seed ethanol extract (NSE) was evaluated in diabetic Meriones shawi. Plasma lipid profile, insulin, leptin, and adiponectin levels were assessed. ACC phosphorylation and Glut4 protein content were determined in liver and skeletal muscle. NSE animals showed a progressive normalization of glycaemia. It seemed to be demonstrate that in vivo treatment with NSE exerts an insulin-sensitizing action by enhancing ACC phosphorylation, a major portion of the insulin-independent AMPK signaling pathway, and also by enhancing muscle Glut4 content
In vitro study of TQ to view whether or not TQ can increase survival and sustain the expression with the homing receptor CD62L in antigen-specific T cells. The results revealed that stimulation of OT-1 (transgenic CD+) T cells with OVA antigen ended in activation, as shown by the decrease from the surface expression of CD62L which coincided with significant apoptosis measured three and five days after antigen stimulation. Addition of low concentrations of TQ during CD85+ T-cell activation led to enhanced survival with the activated T cells and sustained expression of CD62L.