It is also appropriate for use on regular basis in Tibb-e-Nabwi (Prophetic Medicine)<3>.
The fruit is usually a large and inflated capsule consisting of 3-7 united follicles, each containing numerous seeds<9>,<11>.
sativa significantly reduced the elevated ... sugar levels level. The combined 3 compounds significantly increased the degree of insulin and C-peptide. Combination of a-LA, L-carnitine and N. sativa will contribute significantly in improvement in the carbohydrate metabolism in diabetic rats, thus raising the rate of success in therapy for DM<46>. The connection between N. sativa aqueous extract and oil, along with TQ, on serum insulin and glucose concentrations in streptozotocin diabetic rats were studied. Serum insulin and glucose concentrations, SOD levels, and pancreatic tissue malondialdehyde (MDA) were determined. Electron microscopy was utilized to identify any subcellular changes. Diabetes increased tissue MDA and serum sugar levels and decreased insulin and SOD levels. Treatment of rats with N. sativa extract and oil, along with TQ, significantly decreased the diabetes-induced increases in tissue MDA and serum glucose and significantly increased serum insulin and tissue SOD. Ultrastructurally, TQ ameliorated almost all of the toxic results of streptozotocine(STZ), including segregated nucleoli, heterochromatin aggregates (indicating DNA damage), and mitochondrial vacuolization and fragmentation. The aqueous extract of N. sativa also reversed these results of STZ, but to some lesser extent. The N. sativa oil restored normal insulin levels, but neglected to decrease serum glucose concentrations to normalcy. The biochemical and ultrastructural findings claim that N. sativa extract and TQ have therapeutic and control STZ-diabetes by decreasing oxidative stress, thus preserving pancreatic ß-cell integrity. The hypoglycemic effect observed could be as a result of amelioration of ß-cell ultrastructure, thus ultimately causing increased insulin levels. N. sativa and TQ may prove clinically useful inside the treatment of diabetics and from the protection of ß-cells against oxidative stress<47>. The protective effects from the volatile oil of N. sativa seeds on insulin immunoreactivity and ultrastructural changes of pancreatic ß-cells in STZ-induced diabetic rats was reported by Kanter et al. 2009. STZ was injected intraperitoneally for a single dose of 50 mg/kg to induce diabetes. Increased power of staining for insulin, and preservation of ß-cell numbers were apparent inside the N. sativa-treated diabetic rats. The protective effect of N. sativa on STZ-diabetic rats was evident by way of a moderate increase inside lowered secretory vesicles with granules and in addition slight destruction with loss in cristae from the mitochondria of ß-cell when comparing control rats. It is evident that N. sativa treatment exerts a therapeutic protective effect in diabetes by decreasing morphological changes and preserving pancreatic ß-cell integrity<48>. The antihyperglycemic potential of TQ on those activities of key enzymes of carbohydrate metabolism in streptozotocin (STZ)-nicotinamide (NA)-induced diabetic rats was evaluated. Oral administration of TQ at 20, 40, 80 mg/kg body mass for 45 d, dose dependently improved the glycemic status in STZ-NA induced diabetic rats. It have also been demonstrate that in vivo treatment with NSE exerts an insulin-sensitizing action by enhancing ACC phosphorylation, a major part of the insulin-independent AMPK signaling pathway, and also enhancing muscle Glut4 content
The fruit is usually a large and inflated capsule consisting of 3-7 united follicles, each containing numerous seeds<9>,<11>.
sativa significantly reduced the elevated ... sugar levels level. The combined 3 compounds significantly increased the degree of insulin and C-peptide. Combination of a-LA, L-carnitine and N. sativa will contribute significantly in improvement in the carbohydrate metabolism in diabetic rats, thus raising the rate of success in therapy for DM<46>. The connection between N. sativa aqueous extract and oil, along with TQ, on serum insulin and glucose concentrations in streptozotocin diabetic rats were studied. Serum insulin and glucose concentrations, SOD levels, and pancreatic tissue malondialdehyde (MDA) were determined. Electron microscopy was utilized to identify any subcellular changes. Diabetes increased tissue MDA and serum sugar levels and decreased insulin and SOD levels. Treatment of rats with N. sativa extract and oil, along with TQ, significantly decreased the diabetes-induced increases in tissue MDA and serum glucose and significantly increased serum insulin and tissue SOD. Ultrastructurally, TQ ameliorated almost all of the toxic results of streptozotocine(STZ), including segregated nucleoli, heterochromatin aggregates (indicating DNA damage), and mitochondrial vacuolization and fragmentation. The aqueous extract of N. sativa also reversed these results of STZ, but to some lesser extent. The N. sativa oil restored normal insulin levels, but neglected to decrease serum glucose concentrations to normalcy. The biochemical and ultrastructural findings claim that N. sativa extract and TQ have therapeutic and control STZ-diabetes by decreasing oxidative stress, thus preserving pancreatic ß-cell integrity. The hypoglycemic effect observed could be as a result of amelioration of ß-cell ultrastructure, thus ultimately causing increased insulin levels. N. sativa and TQ may prove clinically useful inside the treatment of diabetics and from the protection of ß-cells against oxidative stress<47>. The protective effects from the volatile oil of N. sativa seeds on insulin immunoreactivity and ultrastructural changes of pancreatic ß-cells in STZ-induced diabetic rats was reported by Kanter et al. 2009. STZ was injected intraperitoneally for a single dose of 50 mg/kg to induce diabetes. Increased power of staining for insulin, and preservation of ß-cell numbers were apparent inside the N. sativa-treated diabetic rats. The protective effect of N. sativa on STZ-diabetic rats was evident by way of a moderate increase inside lowered secretory vesicles with granules and in addition slight destruction with loss in cristae from the mitochondria of ß-cell when comparing control rats. It is evident that N. sativa treatment exerts a therapeutic protective effect in diabetes by decreasing morphological changes and preserving pancreatic ß-cell integrity<48>. The antihyperglycemic potential of TQ on those activities of key enzymes of carbohydrate metabolism in streptozotocin (STZ)-nicotinamide (NA)-induced diabetic rats was evaluated. Oral administration of TQ at 20, 40, 80 mg/kg body mass for 45 d, dose dependently improved the glycemic status in STZ-NA induced diabetic rats. It have also been demonstrate that in vivo treatment with NSE exerts an insulin-sensitizing action by enhancing ACC phosphorylation, a major part of the insulin-independent AMPK signaling pathway, and also enhancing muscle Glut4 content
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