It is also suited to use on regular basis in Tibb-e-Nabwi (Prophetic Medicine)<3>.
The fruit is really a large and inflated capsule consists of 3-7 united follicles, each containing numerous seeds<9>,<11>.
Result demonstrated that, protection with AGE and NSO prevented the majority of the hematological and biochemical changes and markedly improved the antioxidant capacity of schistosomiasis mice compared for the infected-untreated ones. These results suggested that AGE and NSO might be promising agents to check schistosomiasis specific treatment
The antioxidant and antiarthritic activity of TQ in Wistar rat by collagen induced arthritis was evaluated. TQ was administered in a dose of 5 mg/kg body volume once daily for 21 d. The outcomes of treatment inside the rats were assessed by biochemical (articular elastase, myeloperoxdase (MPO), LPO, glutathione (GSH), catalase (CAT), SOD and NO), inflammatory mediators <IL-1ß, IL-6, TNF-a, IL-10, IFN-? and PGE(2)> and histological studies in joints. TQ was effective in bringing significant changes on all of the parameters (articular elastase, MPO, LPO, GSH, CAT, SOD and NO) studied. Oral administration of TQ ended in significantly reduced the degree of pro-inflammatory mediators <IL-1ß, IL-6, TNF-a, IFN-? and PGE (2)> and increased degree of IL-10<37>. The antioxidant, anti-inflammatory, anticancer and antibacterial activities with the shoots, roots and seeds methanol extracts from N. sativa were studied. The three organs exhibited strong antioxidant activity while using the oxygen radical absorbance capacity method plus a cell-based assay<38>. TQ may be shown to suppress the Fe-NTA-induced oxidative stress, hyperproliferative response and renal carcinogenesis in Wistar rats<39>. It was suggested that dietary supplementation of black seeds powder inhibits the oxidative stress brought on by oxidized corn oil in rats<40>. It had also been reported that oral feeding with the diet containing black seed powder at 10% level antagonized the oxidative stress effects induced by hepato-carcinogens like dibutylamine and Sodium Nitrate (NaNO3) in Swiss albino rats by normalizing GSH and NO levels<41>. The black seed oil and TQ by intraperitonial injection were found to shown protective effects on lipid peroxidation process during ischemia-reperfusion injury (IRI) in rat hippocampus<42>. Treating broiler chicks with black seed for 6 weeks prevented the liver from oxidative stress by increasing those actions of enzymes for instance myeloperoxidase, glutathione-S-transferase, CAT, adenosine deaminase, myeloperoxidaseand bydecreasing hepatic lipid peroxidation<43>. The crude methanolic extract of black cumin seed cake was discovered to shown with significant antioxidant properties under in vitro systems<44>.The modulatory effect of TQ on erythrocyte lipid peroxidation and antioxidant status during 1,2-dimethylhydrazine- (DMH-) induced colon carcinogenesis after initiation in male Wistar rats was investigated and The TQ pre-treatment restored the increased volume of malondialdehyde and conjugated diene levels, plus an augmentation of enzyme activities like CAT, glutathione peroxidase, and SOD activities caused by exposure to DMH. TQ would be a useful compound preventing DMH-induced erythrocyte damages
It have also been demonstrate that in vivo treatment with NSE exerts an insulin-sensitizing action by enhancing ACC phosphorylation, a major aspect of the insulin-independent AMPK signaling pathway, and also enhancing muscle Glut4 content
The fruit is really a large and inflated capsule consists of 3-7 united follicles, each containing numerous seeds<9>,<11>.
Result demonstrated that, protection with AGE and NSO prevented the majority of the hematological and biochemical changes and markedly improved the antioxidant capacity of schistosomiasis mice compared for the infected-untreated ones. These results suggested that AGE and NSO might be promising agents to check schistosomiasis specific treatment
The antioxidant and antiarthritic activity of TQ in Wistar rat by collagen induced arthritis was evaluated. TQ was administered in a dose of 5 mg/kg body volume once daily for 21 d. The outcomes of treatment inside the rats were assessed by biochemical (articular elastase, myeloperoxdase (MPO), LPO, glutathione (GSH), catalase (CAT), SOD and NO), inflammatory mediators <IL-1ß, IL-6, TNF-a, IL-10, IFN-? and PGE(2)> and histological studies in joints. TQ was effective in bringing significant changes on all of the parameters (articular elastase, MPO, LPO, GSH, CAT, SOD and NO) studied. Oral administration of TQ ended in significantly reduced the degree of pro-inflammatory mediators <IL-1ß, IL-6, TNF-a, IFN-? and PGE (2)> and increased degree of IL-10<37>. The antioxidant, anti-inflammatory, anticancer and antibacterial activities with the shoots, roots and seeds methanol extracts from N. sativa were studied. The three organs exhibited strong antioxidant activity while using the oxygen radical absorbance capacity method plus a cell-based assay<38>. TQ may be shown to suppress the Fe-NTA-induced oxidative stress, hyperproliferative response and renal carcinogenesis in Wistar rats<39>. It was suggested that dietary supplementation of black seeds powder inhibits the oxidative stress brought on by oxidized corn oil in rats<40>. It had also been reported that oral feeding with the diet containing black seed powder at 10% level antagonized the oxidative stress effects induced by hepato-carcinogens like dibutylamine and Sodium Nitrate (NaNO3) in Swiss albino rats by normalizing GSH and NO levels<41>. The black seed oil and TQ by intraperitonial injection were found to shown protective effects on lipid peroxidation process during ischemia-reperfusion injury (IRI) in rat hippocampus<42>. Treating broiler chicks with black seed for 6 weeks prevented the liver from oxidative stress by increasing those actions of enzymes for instance myeloperoxidase, glutathione-S-transferase, CAT, adenosine deaminase, myeloperoxidaseand bydecreasing hepatic lipid peroxidation<43>. The crude methanolic extract of black cumin seed cake was discovered to shown with significant antioxidant properties under in vitro systems<44>.The modulatory effect of TQ on erythrocyte lipid peroxidation and antioxidant status during 1,2-dimethylhydrazine- (DMH-) induced colon carcinogenesis after initiation in male Wistar rats was investigated and The TQ pre-treatment restored the increased volume of malondialdehyde and conjugated diene levels, plus an augmentation of enzyme activities like CAT, glutathione peroxidase, and SOD activities caused by exposure to DMH. TQ would be a useful compound preventing DMH-induced erythrocyte damages
It have also been demonstrate that in vivo treatment with NSE exerts an insulin-sensitizing action by enhancing ACC phosphorylation, a major aspect of the insulin-independent AMPK signaling pathway, and also enhancing muscle Glut4 content