It is also suited to use on regular basis in Tibb-e-Nabwi (Prophetic Medicine)<3>.
The fruit is usually a large and inflated capsule made up of 3-7 united follicles, each containing numerous seeds<9>,<11>.
These results claim that NSO may play a role contrary to the alterations brought on by S. mansoni infection<34>. Results of in vitro testing of N. sativa seeds against Schistosoma mansoni, miracidia, cercariae, and adult worms indicate its strong biocidal effects against all stages on the parasite as well as an inhibitory relation to egg-laying of adult female worms. N. sativa seeds also induced an oxidative stress against adult worms which indicated with a decrease from the activities of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase, and glutathione reductase and enzymes of glucose metabolism, hexokinase and glucose-6-phosphate dehydrogenase. Disturbing of these enzymes of adult worms using N. sativa seeds could consequently render the parasite at risk of damage through the host and might play a role within the anti-schistosomal potency in the N. sativa seed<35>. The antioxidant and anti-schistosomal activities with the garlic extract (AGE) and NSO on normal and Schistosoma mansoni-infected mice was investigated. Result indicated that, protection with AGE and NSO prevented the majority of the hematological and biochemical changes and markedly improved the antioxidant capacity of schistosomiasis mice compared on the infected-untreated ones. These results suggested that AGE and NSO could be promising agents to enhance schistosomiasis specific treatment
The antioxidant and antiarthritic activity of TQ in Wistar rat by collagen induced arthritis was evaluated. TQ was administered with a dose of 5 mg/kg body mass once daily for 21 d. The outcomes of treatment inside the rats were assessed by biochemical (articular elastase, myeloperoxdase (MPO), LPO, glutathione (GSH), catalase (CAT), SOD and NO), inflammatory mediators <IL-1ß, IL-6, TNF-a, IL-10, IFN-? and PGE(2)> and histological studies in joints. TQ was effective in bringing significant changes on all of the parameters (articular elastase, MPO, LPO, GSH, CAT, SOD and NO) studied. Oral administration of TQ generated significantly reduced the amount of pro-inflammatory mediators <IL-1ß, IL-6, TNF-a, IFN-? and PGE (2)> and increased a higher level IL-10<37>. The antioxidant, anti-inflammatory, anticancer and antibacterial activities on the shoots, roots and seeds methanol extracts from N. sativa were studied. The three organs exhibited strong antioxidant activity with all the oxygen radical absorbance capacity method and also a cell-based assay<38>. TQ continues to be shown to suppress the Fe-NTA-induced oxidative stress, hyperproliferative response and renal carcinogenesis in Wistar rats<39>. N. sativa oil has a substantial activity in diabetic and dyslipidemic patients<51>. N. sativa is of immense therapeutic benefit in diabetic individuals and people with glucose intolerance mainly because it accentuates glucose-induced secretion of insulin besides using a negative affect glucose absorption from your intestinal mucosa<52>. The effects with the TQ in STZ-induced diabetes in rats were investigated. It seemed to be demonstrate that in vivo treatment with NSE exerts an insulin-sensitizing action by enhancing ACC phosphorylation, a major part of the insulin-independent AMPK signaling pathway, through enhancing muscle Glut4 content
The fruit is usually a large and inflated capsule made up of 3-7 united follicles, each containing numerous seeds<9>,<11>.
These results claim that NSO may play a role contrary to the alterations brought on by S. mansoni infection<34>. Results of in vitro testing of N. sativa seeds against Schistosoma mansoni, miracidia, cercariae, and adult worms indicate its strong biocidal effects against all stages on the parasite as well as an inhibitory relation to egg-laying of adult female worms. N. sativa seeds also induced an oxidative stress against adult worms which indicated with a decrease from the activities of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase, and glutathione reductase and enzymes of glucose metabolism, hexokinase and glucose-6-phosphate dehydrogenase. Disturbing of these enzymes of adult worms using N. sativa seeds could consequently render the parasite at risk of damage through the host and might play a role within the anti-schistosomal potency in the N. sativa seed<35>. The antioxidant and anti-schistosomal activities with the garlic extract (AGE) and NSO on normal and Schistosoma mansoni-infected mice was investigated. Result indicated that, protection with AGE and NSO prevented the majority of the hematological and biochemical changes and markedly improved the antioxidant capacity of schistosomiasis mice compared on the infected-untreated ones. These results suggested that AGE and NSO could be promising agents to enhance schistosomiasis specific treatment
The antioxidant and antiarthritic activity of TQ in Wistar rat by collagen induced arthritis was evaluated. TQ was administered with a dose of 5 mg/kg body mass once daily for 21 d. The outcomes of treatment inside the rats were assessed by biochemical (articular elastase, myeloperoxdase (MPO), LPO, glutathione (GSH), catalase (CAT), SOD and NO), inflammatory mediators <IL-1ß, IL-6, TNF-a, IL-10, IFN-? and PGE(2)> and histological studies in joints. TQ was effective in bringing significant changes on all of the parameters (articular elastase, MPO, LPO, GSH, CAT, SOD and NO) studied. Oral administration of TQ generated significantly reduced the amount of pro-inflammatory mediators <IL-1ß, IL-6, TNF-a, IFN-? and PGE (2)> and increased a higher level IL-10<37>. The antioxidant, anti-inflammatory, anticancer and antibacterial activities on the shoots, roots and seeds methanol extracts from N. sativa were studied. The three organs exhibited strong antioxidant activity with all the oxygen radical absorbance capacity method and also a cell-based assay<38>. TQ continues to be shown to suppress the Fe-NTA-induced oxidative stress, hyperproliferative response and renal carcinogenesis in Wistar rats<39>. N. sativa oil has a substantial activity in diabetic and dyslipidemic patients<51>. N. sativa is of immense therapeutic benefit in diabetic individuals and people with glucose intolerance mainly because it accentuates glucose-induced secretion of insulin besides using a negative affect glucose absorption from your intestinal mucosa<52>. The effects with the TQ in STZ-induced diabetes in rats were investigated. It seemed to be demonstrate that in vivo treatment with NSE exerts an insulin-sensitizing action by enhancing ACC phosphorylation, a major part of the insulin-independent AMPK signaling pathway, through enhancing muscle Glut4 content